FHIR Osiris Implementation Guide
1.1.0 - trial-implementation

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## : Biomarker Value Set - JSON Representation

Draft as of 2025-04-03

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    {
      "resourceType" : "ValueSet",
      "id" : "BiomarkerCode",
      "text" : {
        "status" : "generated",
        "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: ValueSet BiomarkerCode</b></p><a name=\"BiomarkerCode\"> </a><a name=\"hcBiomarkerCode\"> </a><a name=\"BiomarkerCode-en-US\"> </a><ul><li>Include ces codes sont définis dans <code>https://github.com/siric-osiris/OSIRIS</code><table class=\"none\"><tr><td style=\"white-space:nowrap\"><b>Code</b></td><td><b>Display</b></td></tr><tr><td>C39-1</td><td>CKIT</td></tr><tr><td>C39-2</td><td>b-catenine</td></tr><tr><td>C39-3</td><td>CKIT/DOG1</td></tr><tr><td>C39-4</td><td>FOXL2/DICER</td></tr><tr><td>C39-5</td><td>ETV6-NTRK3</td></tr><tr><td>C39-6</td><td>MYB-NFIB</td></tr><tr><td>C39-7</td><td>PDGFRA/FGFR1</td></tr><tr><td>C39-8</td><td>MDM2</td></tr><tr><td>C39-9</td><td>N-MYC</td></tr><tr><td>C39-10</td><td>C-MYC</td></tr><tr><td>C39-11</td><td>BCR-ABL1</td></tr><tr><td>C39-12</td><td>COL1A1</td></tr><tr><td>C39-13</td><td>DDIT3</td></tr><tr><td>C39-14</td><td>EWSR2</td></tr><tr><td>C39-15</td><td>SYT</td></tr><tr><td>C39-16</td><td>CTNNB1</td></tr><tr><td>C39-17</td><td>FUS</td></tr><tr><td>C39-18</td><td>IGH-BCL2</td></tr><tr><td>C39-19</td><td>JAZF1</td></tr><tr><td>C39-20</td><td>FOXO1A</td></tr><tr><td>C39-21</td><td>TFE3</td></tr><tr><td>C39-22</td><td>HPV</td></tr><tr><td>C39-23</td><td>Merkell</td></tr><tr><td>C39-24</td><td>EBER</td></tr><tr><td>C39-25</td><td>PSA</td></tr><tr><td>C39-26</td><td>CA125</td></tr><tr><td>C39-27</td><td>CA153</td></tr><tr><td>C39-28</td><td>CA199</td></tr><tr><td>C39-29</td><td>Ki67</td></tr><tr><td>C39-30</td><td>Nb mitoses</td></tr><tr><td>C39-31</td><td>RO</td></tr><tr><td>C39-32</td><td>RP</td></tr><tr><td>C39-33</td><td>HER2</td></tr><tr><td>C39-34</td><td>PD-L1</td></tr><tr><td>C39-35</td><td>AMHR2</td></tr><tr><td>C39-36</td><td>P53</td></tr><tr><td>C39-37</td><td>BRCA</td></tr><tr><td>C39-38</td><td>MSI</td></tr><tr><td>C39-39</td><td>CDK12</td></tr><tr><td>C39-40</td><td>BRAF</td></tr><tr><td>C39-41</td><td>NRAS-KRAS</td></tr><tr><td>C39-42</td><td>EGFR</td></tr><tr><td>C39-43</td><td>ALK</td></tr><tr><td>C39-44</td><td>ROS1</td></tr><tr><td>C39-45</td><td>C-MET</td></tr><tr><td>C39-46</td><td>ESR1</td></tr><tr><td>C39-47</td><td>PAM50</td></tr><tr><td>C39-48</td><td>ENDOPREDICT</td></tr></table></li></ul></div>"
      },
      "url" : "https://ig-osiris.cancer.fr/ig/osiris/ValueSet/BiomarkerCode",
      "version" : "1.1.0",
      "name" : "BiomarkerCode",
      "title" : "Biomarker Value Set",
      "status" : "draft",
      "date" : "2025-04-03T14:14:07+02:00",
      "publisher" : "institutcancer",
      "contact" : [
        {
          "name" : "institutcancer",
          "telecom" : [
            {
              "system" : "url",
              "value" : "http://cancer.fr"
            },
            {
              "system" : "email",
              "value" : "osiris@institutcancer.fr"
            }
          ]
        },
        {
          "name" : "Aurélien JOBARD",
          "telecom" : [
            {
              "system" : "email",
              "value" : "osiris@institutcancer.fr"
            }
          ]
        }
      ],
      "description" : "Biomarker types",
      "compose" : {
        "include" : [
          {
            "system" : "https://github.com/siric-osiris/OSIRIS",
            "concept" : [
              {
                "code" : "C39-1",
                "display" : "CKIT"
              },
              {
                "code" : "C39-2",
                "display" : "b-catenine"
              },
              {
                "code" : "C39-3",
                "display" : "CKIT/DOG1"
              },
              {
                "code" : "C39-4",
                "display" : "FOXL2/DICER"
              },
              {
                "code" : "C39-5",
                "display" : "ETV6-NTRK3"
              },
              {
                "code" : "C39-6",
                "display" : "MYB-NFIB"
              },
              {
                "code" : "C39-7",
                "display" : "PDGFRA/FGFR1"
              },
              {
                "code" : "C39-8",
                "display" : "MDM2"
              },
              {
                "code" : "C39-9",
                "display" : "N-MYC"
              },
              {
                "code" : "C39-10",
                "display" : "C-MYC"
              },
              {
                "code" : "C39-11",
                "display" : "BCR-ABL1"
              },
              {
                "code" : "C39-12",
                "display" : "COL1A1"
              },
              {
                "code" : "C39-13",
                "display" : "DDIT3"
              },
              {
                "code" : "C39-14",
                "display" : "EWSR2"
              },
              {
                "code" : "C39-15",
                "display" : "SYT"
              },
              {
                "code" : "C39-16",
                "display" : "CTNNB1"
              },
              {
                "code" : "C39-17",
                "display" : "FUS"
              },
              {
                "code" : "C39-18",
                "display" : "IGH-BCL2"
              },
              {
                "code" : "C39-19",
                "display" : "JAZF1"
              },
              {
                "code" : "C39-20",
                "display" : "FOXO1A"
              },
              {
                "code" : "C39-21",
                "display" : "TFE3"
              },
              {
                "code" : "C39-22",
                "display" : "HPV"
              },
              {
                "code" : "C39-23",
                "display" : "Merkell"
              },
              {
                "code" : "C39-24",
                "display" : "EBER"
              },
              {
                "code" : "C39-25",
                "display" : "PSA"
              },
              {
                "code" : "C39-26",
                "display" : "CA125"
              },
              {
                "code" : "C39-27",
                "display" : "CA153"
              },
              {
                "code" : "C39-28",
                "display" : "CA199"
              },
              {
                "code" : "C39-29",
                "display" : "Ki67"
              },
              {
                "code" : "C39-30",
                "display" : "Nb mitoses"
              },
              {
                "code" : "C39-31",
                "display" : "RO"
              },
              {
                "code" : "C39-32",
                "display" : "RP"
              },
              {
                "code" : "C39-33",
                "display" : "HER2"
              },
              {
                "code" : "C39-34",
                "display" : "PD-L1"
              },
              {
                "code" : "C39-35",
                "display" : "AMHR2"
              },
              {
                "code" : "C39-36",
                "display" : "P53"
              },
              {
                "code" : "C39-37",
                "display" : "BRCA"
              },
              {
                "code" : "C39-38",
                "display" : "MSI"
              },
              {
                "code" : "C39-39",
                "display" : "CDK12"
              },
              {
                "code" : "C39-40",
                "display" : "BRAF"
              },
              {
                "code" : "C39-41",
                "display" : "NRAS-KRAS"
              },
              {
                "code" : "C39-42",
                "display" : "EGFR"
              },
              {
                "code" : "C39-43",
                "display" : "ALK"
              },
              {
                "code" : "C39-44",
                "display" : "ROS1"
              },
              {
                "code" : "C39-45",
                "display" : "C-MET"
              },
              {
                "code" : "C39-46",
                "display" : "ESR1"
              },
              {
                "code" : "C39-47",
                "display" : "PAM50"
              },
              {
                "code" : "C39-48",
                "display" : "ENDOPREDICT"
              }
            ]
          }
        ]
      }
    }