FHIR Osiris Implementation Guide
1.1.0 - trial-implementation

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## Requests

These requests are examples of the potential of this IG. These requests will work on each hospital that has a FHIR endpoint using the osiris data model.

### Request Patients with breast cancer (primary or metastatic) with a genetic alteration on TP53.

#### Requests Patient with breast cancer

    Patient?
        gender=female
        &_has:Condition:subject:body-site=C50.9

#### Request Patients with a genetic alteration on TP53 **

    Patient?
        _has:Observation:patient:component-code-value-concept=http://loinc.org|48018-6$http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc|TP53

#### Final request

    Patient?
        gender=female
        &_has:Condition:subject:body-site=C50.9
        &_has:Observation:patient:component-code-value-concept=http://loinc.org|48018-6$http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc|TP53

### Request Patients with colorectal cancer and metastatic with an genetic alteration on KRAS, treated by Bevacizumab and progressing.

#### Request female Patients with a colorectal cancer

    Patient?
        gender=female
        &_has:Condition:subject:body-site=C18.9

#### Request Patients with metastasis

    Condition?
        code=C2939419

#### Request Patients treated by bevacizumab (ATC code L01XC07)

    Patient?
        _has:MedicationStatement:subject:code=L01XC07

#### Request Patients with an genetic alteration on KRAS

    Patient?
        _has:Observation:patient:component-code-value-concept=http://loinc.org|48018-6$http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc|KRAS

#### Request female Patients with a progressing cancer

    Patient?
        gender=female
        &_has:Observation:subject:code-value-concept=https://project.eortc.org/recist|PD

#### Final request

    Patient?
        gender=female
        &_has:Condition:subject:body-site=C18.9
        &_has:Condition:subject:code=C2939419
        &_has:MedicationStatement:subject:code=L01XC07
        &_has:Observation:patient:component-code-value-concept=http://loinc.org|48018-6$http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc|KRAS
        &_has:Observation:subject:code-value-concept=https://project.eortc.org/recist|PD